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Interestingly, the expression of PNPLA2 and PNPLA3 oppose one another, with expression of PNPLA2 highest during conditions that promote TAG hydrolysis such as fasting, while the expression of PNPLA3 is highest during conditions that promote TAG synthesis such as feeding (62, 63)

A GSL Switch is Unlikely in the Current Climate Despite a recent drive by the Department of Health and Social Care (DHSC) to encourage the reclassification of certain medicines (like those for pain, sleep aids, and skin conditions) to P or GSL status, a switch for injectable B12 is not on the cards