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Gene set enrichment analysis (GSEA) was performed with 1000 permutations to identify enriched biological functions and activated pathways from the molecular signatures database (MSigDB), which included hallmark gene sets, positional gene sets, curated gene sets, motif gene sets, computational gene sets, GO gene sets, oncogenic gene sets, and immunologic gene sets

Therefore, we hypothesized that a BBB-crossing dendrimer nanoformulation double-targeting glucose and glutamine metabolism would be able to impair GBM metabolism and survival

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The expression of specific surface markers confirmed the mesenchymal identity of the isolated hGMSCs