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Keratinocytes release cytokines to attract autoreactive T cells

The authors also observed a relevant attenuation of the overactive bladder due to the reduction of contractions during bladder emptying and the reduction of urinary frequency, normalization of detrusor smooth muscle hypercontractility, and restoring urethral relaxation [84]

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Given the highly complex mechanisms of ferroptosis and the fact that OA pathology often involves multiple dysregulated pathways, an integrated, multifaceted treatment approach is required