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Ann Oncol 30(10):1580-1590, 2019

International Journal for Vitamin and Nutrition Research, 90 (1-2), 179194

Smoking also may impair the phase II metabolites, thus creating more estrogen quinone metabolites with a decreased ability to eliminate them.[ref][ref] Therefore, the combo of variants in phase I and phase II genes (genotype report below) with smoking causes a fairly large increase in the risk of cervical, breast, or prostate cancer