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Studies suggest that glutathione depletion is associated with Parkinsons disease progression, making it a target for therapeutic interventions

Since AOMs are indicated in combination with lifestyle interventions, all participants received dietary and physical activity counseling, aiming to achieve a 500-kcal deficit per day and 150 minutes of physical activity per week

10.3324/haematol.2018.190876 Haematologica 57 InamotoY.KimuraF.KandaJ.SugitaJ.IkegameK.NakasoneH.et al (2016)

These modifications preserve IGF-1 receptor (IGF-1R) agonist activity while reducing IGFBP sequestration, enabling sustained receptor engagement in preclinical research models

Blood-brain barrier (BBB) The structural and functional integrity of the BBB is emerging as another early-stage biomarker for neurodegenerative conditions