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Subcutaneous B12 Injections: Key Differences When it comes to Vitamin B12 injections, one of the most critical decisions is choosing whether to administer the injection intramuscularly (IM) or subcutaneously (SC)

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This activates the vitamin so that your body can begin to use it and helps ease any irritation at the injection site

Others who might be prescribed B12 shots are those at the highest risk for a B12 deficiency, including: Vegans, since vitamin B12 is found only in animal products People ages 60 and up since their bodies don't absorb B12 as efficiently People with Crohn's disease or pancreatic disease, since they prevent nutrient absorption People who had weight-loss surgery, which decreases B12 absorption People with an eating disorder People with HIV People with diabetes Since a mild B12 deficiency might not cause symptoms, it can go undetected for years since levels are not checked during routine blood work