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Approximately 10 patients with LS have been identified with pathogenic SDHB variations, most exhibiting neurodegenerative symptoms, seizures, and dystonia, with one patient showing heat sensitivity (72)

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Similarly, ERK (extracellular signal-regulated kinase) and its involvement in melanin synthesis via the ERK/CREB (cAMP response element binding protein) pathway demonstrate how kinases contribute not only to antioxidant defense but also to pigmentation regulation by upregulating MITF and TRP1 69,71

Halliday GM, Stevens CH

What makes them noteworthy is the novelty of their targets: Dihexa works through the hepatocyte growth factor (HGF) / c-Met receptor system, while PE-22-28 blocks TREK-1 two-pore domain potassium channels