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Thus, replacement of leucine 973 C terminal to the NPEY motif in the IR by phenylalanine, the residue found in the homologous region of the IGF1R, is sufficient to largely switch the cell signalling and gene expression patterns toward those of the IGF1R

81 Also, radiographic progression rates measured by an increase in erosion scores of more than 3 units were statistically significantly lower for patients in the MTX group