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Inclusion of case-control studies, which are more susceptible to bias, may explain these discrepancies among meta-analyses (128)

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Figure 2 The neurodegenerative effect mediated by AngII and the AngII-AT 1 R complex are mediated by an increased release of ROS via the NADPH-oxidase complex in microglia and dopaminergic neurons, resulting in a vicious proinflammatory circle (123)

REGEN is generally considered appropriate for adults 21 and older due to limited safety data in younger populations

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