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Animals 13(21):3357

Future designs are likely to place more emphasis on rational simplification: after identifying one or two key TME barriers for a given indication, only functions that are closely aligned with those barriers would be retained, and embedded into carriers with mature manufacturing routes and well-characterized parameters [21]

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194,195 The activated PI3K catalyzes the conversion of membrane phospholipid Phosphatidylinositol-4,5-bisphosphate (PIP2) into Phosphatidylinositol-3,4,5-trisphosphate (PIP3)

10.1038/s12276-020-0459-0 84 RangaswamiJ.BhallaV.BlairJ