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Folic acid remains an effective way to support one-carbon metabolism and lower homocysteine in most people, while methylfolate may offer advantages for some individuals, particularly those with reduced DHFR activity or a poor response to folic acid

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Kshattry, S., Saha, A., Gries, P., Tiziani, S., Stone, E., Georgiou, G

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Plasma and RBCs were aliquoted into separate vials and stored at -20C