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For instance, although pathogenic mtDNA mutations impair cellular metabolism and cause cellular heterogeneity and disease, recent studies have unravelled that different mutations are associated with different clinical phenotypes and that purification choices of T cells also affect pathogenic mtDNA mutations in vivo , which has not been widely validated in RA and still needs to be further explored in the future (171)

VoigtRGMellonMWKatusicSKWeaverALMaternDMellonBet al

Biomaterials 30 , 62026212 (2009)

Our own discussion of BPC157s mechanism can be found in an indepth article on the healing peptide mechanism