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Individuals who may have undiagnosed underlying conditions affecting B12 metabolism

FIGURE 2 A notable advantage of this technique is its ability to achieve deep brain modulation without the need for direct physical access

Instead, research points to activity across multiple interconnected systems, including modulation of the nitric oxide (NO) system, upregulation of growth factor expression (notably VEGF, EGF, and FGF pathways), promotion of angiogenesis, and activation of the FAK-paxillin signalling pathway involved in cell migration and tissue organisation

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This mechanism remains less well characterized than the two previous ones and requires further independent validation