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Alcohol's interference isn't a theoretical concern

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This release of histamine and tryptase increases blood flow to the skeletal muscles during exercise.[ref] Hypoxia has also been shown to induce mast cell degranulation.[ref] This is a normal response for most people, and the body can handle a certain increase in histamine and tryptase

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Collectively, these findings align with broader epidemiological data suggesting that long-term NSW may contribute to BS risk, in part via suppressed immune surveillance mechanisms 11