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The work of Bast and Haenen in the Netherlands frames it cleanly: lipoic acid contributes mainly by keeping glutathione in its reduced, active state, because glutathione is the active antioxidant doing the real work

Acute cisplatin ototoxicity paradigm: Under anesthesia, animals are administered a single intraperitoneal injection of cisplatin (11 mg/kg) over a 30-min period

Bishop NA, Lu T, Yankner BA (2010)