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The copper ion (Cu2+) is an essential cofactor of lysyl oxidase, the enzyme that catalyzes the cross-linking of collagen and elastin, ensuring the three-dimensional structure and mechanical resistance of the extracellular matrix

Among the various NMs, metal-oxide nanoparticles (NPs) such as zinc oxide nanoparticles (ZnONPs), silicon dioxide nanoparticles (SiO 2 NPs), as well as carbon-based NMs like multi-walled carbon nanotubes (MWCNTs), have shown positive effects on in vitro cultures 9

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