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Nanoparticles decorated with ligands for cardiomyocyte-specific receptors enable passive targeting (e.g., the EPR effect), active targeting, and intelligent drug release in response to the pathological microenvironment (e.g., pH and enzymes), ensuring drug enrichment and localized release at the cardiac site [255, 256]

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The GLP-1 ceiling problem Even with the most effective GLP-1 therapies currently available, a significant proportion of patients do not achieve clinically optimal weight loss outcomes