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The plasma levels of cytokines associated with inflammatory reactions (CSF-1, IL-15RA, IL18, MCP-1, and TNF) were significantly downregulated in the intervention group compared to the placebo group on Day 14

Morning versus evening application Evening application advantages: Skin repair processes peak overnight, potentially enhancing copper peptide effects

5.3.1.1 Microglial and ferroptosis Elevated cerebral iron levels activate the NF-B signaling pathway, initiating the classical pro-inflammatory phenotypic transformation of microglia (135)

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