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A 2018 attempt by an independent lab to reproduce the headline neurotrophic effect in vitro reportedly produced mixed results, which is a typical finding when independent groups try to replicate striking preclinical findings

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Counteracted/attenuated were neuroleptics (i.e., catalepsy) [68,70], L-arginine (i.e., prolonged miosis) [86], N(G)-nitro-L-arginine methyl ester (L-NAME) (prolonged miosis, catalepsy) [70,86], and alcohol acute and chronic intoxication [63,64]

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