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Furthermore, the intervals between an inflammatory stimulus, the massive generation and complete activation of lytic enzymes, and the accumulation of glycocalyx degradation products, which causes changes in microvascular permeability that can be relatively prolonged (102)

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doi: 10.1056/NEJMoa2021713 116 StockleyRDe SoyzaAGunawardenaKPerrettJForsman-SembKEntwistleNet al