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These findings underscore the potential of targeting the MAPK signaling pathway as a therapeutic strategy for managing asthma, given its central role in mediating inflammatory and structural changes in the airways [119]

For instance, combining curcumin with ultrasound significantly enhanced apoptotic activity in SiHa and HeLa cells, compared to curcumin monotherapy (73)

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An animal study revealed that proinflammatory factors such as TNF-, IL-6 and MCP-1 were inhibited, the structure of the intestinal microbiota was optimized, and metabolic functions improved after Lacticaseibacillus rhamnosus GG (LGG) pretreatment in a mouse model of RE 99