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This causes depolarization of the cell membrane, action potential progression, and the release of neurotransmitters from the presynaptic terminals (Mark et al., 2001)

The peptide not only reduced pain severity but also decreased the duration and frequency of pain episodes, suggesting its potential as a therapeutic agent for chronic pain management 7

Amylin, a neuroendocrine anorexigenic polypeptide hormone, with its multi-faceted effects in glucose regulation, weight management and potential CV and neuroprotective functions, represents an attractive new therapeutic target, albeit not without challenges and limitations [29]