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The most cited in-vivo work used rat subcutaneous wound chambers, where a test substance is injected into an implanted healing compartment

However, matrix stiffening promotes the dissociation of the Twist1-G3BP2 complex, and the translocation of Twist1 to the nucleus, where it initiates EMT, thereby promoting breast tumor invasion and metastasis [79]

Distinct Nrf2 signaling mechanisms of fumaric acid esters and their role in neuroprotection against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced experimental Parkinsons-like disease