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329,330 In degenerative joint diseases like OA, the metabolic balance of chondrocytes is disrupted, leading to the overproduction of degrading enzymes and inflammatory mediators, including iNOS, MMP-13, and ADAMTS5 (a disintegrin and metalloproteinase with thrombospondin motifs 5), which participate in cartilage degradation and inflammatory processes

Shashi A, Tikka M (2021) Fluoride-induced adrenal insufficiency: adrenocorticotropin endocrine disruption and ultrastructural experimental study

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Post-treatment, the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) 2000 score declined from 8 to 4 over a two-year period, and levels of complement components C3 and C4 returned to normal