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Acknowledgements We thank the University of Maine Animal Facility staff for their assistance with animal care and handling, and the University of Maine Food Pilot Plant for their help with diet preparation

Two aliquots of 150 L/tube were prepared for each sample and frozen at - 80C

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Lancet Oncol 15(10):e447e460 Martnez ME, Jacobs ET, Baron JA, Marshall JR, Byers T (2012) Dietary supplements and cancer prevention: balancing potential benefits against proven harms