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In the context of severe intestinal lesions such as the crypt loss observed in inflammatory bowel disease (IBD), LGR5 + intestinal stem cells (ISCs) vigorously proliferate and differentiate to replenish the cellular pool essential for restoring the epithelial barrier, thus promoting epithelial regeneration post-injury 1,2

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Thomas DA, Faderal S, Cortes J, O'Brien S, Giles F, Garcia-Manero G, Kornblau S, Andreeff M, Beran M, Verstovsek S, Pierce S, Letvak L, Salvado A, Champlin R, Kantarjian H

Written informed consent was obtained from all participants, and all ethical regulations relevant to human research were followed

Guo Y, Zang Y, Lv L, Cai F, Qian T, Zhang G, Feng Q