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Moreover, intracellular lipid accumulation or supplementation with exogenous fatty acids can trigger the generation of reactive oxygen species (ROS) and the secretion of immunosuppressive cytokines, thereby facilitating the polarization of macrophages toward a pro-tumorigenic M2 phenotype, which in turn enhances tumor cell invasiveness and metastatic potential (87)

In this context, a sub-multiplicative interaction refers to a joint effect that is greater than additive but less than multiplicative, as defined by Laurier et al

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