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Gains in knowledge may accelerate the design and synthesis of effective inhibitors (for a profound review paper see Kafarski and Talma (2018))

Using expired vials introduces uncontrolled variables that compromise study reproducibility

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Other conditions that make Vitamin B12 absorption more difficult are: Weight loss surgery or another operation that removed part of your stomach Heavy drinking Taking acid-reducing medication for a long time Certain health issues may also lead to the development of vitamin B12 deficiency such as atrophic gastritis, pernicious anemia, Crohns disease, celiac disease, immune system disorders, Graves disease and lupus

Vitamin B12 deficiency is associated with cognitive problems (problems with thinking, judgment, and learning) and memory issues