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PT2385 binds to the PAS-B domain of HIF-2, a region crucial for heterodimerization with HIF-1 (ARNT), effectively preventing DNA binding and transcriptional activation of downstream oncogenic targets such as VEGF, cyclin D1, and GLUT1 (187)

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The most common side effects are [2, 3, 4]: Gastrointestinal side effects, like nausea, vomiting, diarrhoea, constipation, indigestion or heartburn Decreased appetite and/or thirstmake sure you drink plenty of water to stay hydrated and eat nutritious, balanced meals

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