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O 2 consumption by the PDO domain is abolished by the C201A and C408A substitutions revealing tight coupling of the two active sites

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GGCT expresses higher and correlates positively with Gln in a dose-dependent manner in tumor cells Given Glns role in GSH synthesis, we analyzed GSH metabolism gene expression in HCC and PCa using the GEPIA database

This leaves you open to oxidative damage caused by reactive oxygen species (aka free radicals)