This caliber of high impact workout requires the extremely efficient use of oxygen in skeletal muscle and often creates an oxidative dilemma that may increase free radical production
Liu, Y., et al., Alpha-lipoic acid improves high-fat diet-induced hepatic steatosis by modulating the transcription factors SREBP-1, FoxO1 and Nrf2 via the SIRT1/LKB1/AMPK pathway
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showed that curcumin effectively counteracts doxorubicin (DOX)-induced neurotoxicity by suppressing autophagy while reducing oxidative and endoplasmic reticulum stress, with these protective effects mediated through activation of the Keap1-Nrf2-ARE signaling pathway
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