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Further, our motif discovery analyses support the hypothesis that epigenetic remodelling in the USCs occurs primarily at AP-1-associated DARs in response to a self-limiting acute infection (resolved-accessible DARs), but that severe acute infection leading to chronic infection and inflammation (sensitized-accessible DARs) induces epigenetic remodelling not only at AP-1-associated DARs, but also at additional TF-associated DARs, such as those with Klf and Sox family motif sites

In the nervous system, it plays a positive role in maintaining cognitive function and long-term nervous system health by reducing oxidative stress levels and decreasing nerve cell damage and apoptosis

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Innate Immune Sensing and Signaling of Cytosolic Nucleic Acids