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To visualize small-molecule metabolites localized within TLS, we used matrix-assisted laser desorption/ionization time of flight imaging mass spectrometry and found significant accumulation of glutathione (reduced form: glutathione [GSH], oxidized form: glutathione disulfide [GSSG]) within TLS (Figure 1C)

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A: Complexes of calcitonin receptors with receptor activity-modifying proteins (RAMPs), expressed in the area postrema and hypothalamus key regions regulating appetite and energy balance