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Peer review Peer review information Nature Cancer thanks Daniel Herranz and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

Because L-Citrulline largely bypasses first-pass liver metabolism (where some L-Arginine is broken down before reaching the bloodstream), research suggests that L-Citrulline may raise plasma L-Arginine levels more efficiently, gram for gram, than supplementing L-Arginine directly

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Introduction Progressive segmental glomerulosclerosis or extreme loss of glomerulus filtration rate are generally acknowledged as the main characteristics of CKD [1]