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MGF expression is significantly increased in muscle, bone, and tendon following damage from mechanical stimuli and in the brain and heart following ischaemia with expression preceding that of IGF-1Ea after injury, suggesting that the two alternative splice forms serve distinct and sequential roles in tissue research applications and repair

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Most of these cases result in a condition known as a blighted ovum in which no embryo forms.[7] This is often the result of damage or mutation to the fertilized egg or sperm cell and does not necessarily extend to the rest of either in each parent

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