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Multiple studies have shown that GPER activation may improve insulin resistance by regulating insulin receptor substrates (IRSs) and the PI3K signaling pathway, thereby amplifying the biological effects of insulin [4, 174]

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Atherosclerosis 219 (2), 869874 (2011)

or suppressing p27Kip1 degradation

Furthermore, an increased plasma von Willebrand factor is found in hyperhomocysteinemic subjects bearing premature arterial disease (Freyburger et al, 1997) and, of major relevance, acute methionine loading induced moderate hyperhomocysteinemia results in a significant increase in von Willebrand factor (Constant et al, 1999)