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Glucagon-Like Peptide-1 Protects Beta-Cells Against Apoptosis by Increasing the Activity of an IGF-2/IGF-1 Receptor Autocrine Loop

But surrounding this core is the ischemic penumbra, a larger region of at-risk tissue that is damaged but not yet dead

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Respiratory depression is the chief risk for elderly patients treated with opioids, and has occurred after large initial doses were administered to patients who were not opioid-tolerant or when opioids were co-administered with other agents that depress respiration