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Intracorporeal plaque (Peyronies plaques within the corpora) is a relatively rare type of the disease unless the patient receives PGE injections

Research confirms it maintains this selectivity even at extremely high dosages, ensuring that experimental observations reflect pure growth hormone signaling rather than multi-hormonal activation This molecular precision is critical for mechanistic research, where hormonal cross-activation, such as stimulation of the hypothalamic-pituitary-adrenal (HPA) axis, would otherwise confound the data

IGF-1 is posited to be the main mediator of GHs anabolic actions

The analogy is imperfect, since topical application produces subtler and more gradual results, but the mechanism is related