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The key is how these signals are structured and integrated within the tissue

Genes encoding membrane transporters are also critical to the normal responses of -cells to glucose metabolism including KCNJ8 (K ir 6.1), KCNJ11 (K ir 6.2), KCNQ1 (K v 7.1), SLC39A11 (zinc transporter), SLC30A8, and SLC22A18

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Indeed, as discussed below, this is very difficult to establish

doi: 10.7150/ijbs.35128 20 ChapronCVannucciniSSantulliPAbroMSCarmonaFFraserISet al