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Repair proceeds through overlapping phases: hemostasis, inflammation, proliferation (angiogenesis, fibroplasia, matrix deposition), and remodeling (maturation and cross-linking of the matrix)

Oxidative stress-induced DNA damage of mouse zygotes triggers G2/M checkpoint and phosphorylates Cdc25 and Cdc2

But too much IGF-1 also can allow damaged cells to continue growing

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Neuron 110:34843496 Morand A, Campion JY, Lepine A, Bosdure E, Luciani L, Cammilleri S, Chabrol B, Guedj E (2022) Similar patterns of [ (18) F]-FDG brain pet hypometabolism in paediatric and adult patients with long covid: a paediatric case series