While not everyone with IgG4-RD experiences headaches, the disease can impact areas that lead to persistent or severe headaches, such as: The meninges: These protective brain layers can thicken and become inflamed (hypertrophic pachymeningitis), resulting in ongoing, sometimes debilitating headaches
Although these stages are presented as an orderly progression, clinically that is not always the case
If not enough glutathione is being produced relative to the oxidative or free radical load present, then the free radicals, seeking balance, will rip holes in the neighboring cells and neuroinflammation will occur
In KO mice deficient of another Rac1 GAP protein, ArhGAP15, the hyperactive Rac1 led to longer escaping latency during the reversal phases in the water maze test without affecting the learning process, as well as less freezing in both contextual and cued fear memory test (Zamboni et al., 2016)
PMID: 28370978 Parker NP, Ardeshirpour F, Schmechel SC, et al