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Intracellular metabolites (GSH, glucose, glucose-6P, pyruvate, succinate) were measured by liquid chromatography (Vanquish HPLC Thermo Scientific) coupled to high resolution mass spectrometry (QExactive HF Thermo Scientific)

Moreover, the beneficial effects of melatonin on mouse hearts, which depend on the regulation of ALDH2 activity, could not be assessed due to mutations or deficiencies in ALDH2

Sudo K, Xiao L, Wadhwa R, Taketa T, Blum MA, Skinner HD, Lee JH, Bhutani MS, Weston B, Komaki R, Rice DC , Swisher SG, Hofstetter WL, Ajani JA

WBCs, focused on clearing debris and repairing tissue, may attack healthy cells, triggering autoimmune inflammation and altering organ function