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The Trx system plays a key role in DNA synthesis, anti-apoptotic signaling, and regulation of redox-sensitive transcription factors

In: Fundamentals of Anesthesiology

Estrogen has been shown to upregulate endogenous MOTS-c expression in preclinical models, which may partly explain why metabolic deterioration accelerates in perimenopause when estrogen falls precipitously [2]

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Ultimately, the activated NMIIA continues to act on its downstream target, Itgb2, regulating its kinetics and localization on the plasma membrane (PM) to promote the stasis of rigid neutrophils (87)