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What makes Dihexa especially intriguing is that, unlike many peptides, it can cross the blood-brain barrier and directly interact with the nervous system
DOI: 10.5599/admet.1.4.24 Since direct prediction of implicit solubility yielded inferior results to aqueous-solubility prediction ( vide supra ), pHsolubility curves were generated by (1) predicting aqueous solubility at a neutral pH , (2) converting aqueous solubility to intrinsic solubility by multiplying by the Starling-computed at pH , and (3) multiplying this by to convert back to aqueous solubility at different pH values
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For the pressure recordings in the superior sagittal sinus, portal vein, vena cava, and abdominal aorta (throughout 5 min), medication (10 g/kg BPC 157, 10 ng/kg BPC 157 or 5 mL/kg saline) (i) intraperitoneally or (ii) intragastrically or (iii) topically at the swollen brain through an additional midline burr hole
The compliance with planning, the knowledge of protocols and the coordination between actors will be some of the factors that will be evaluated
