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Darkening of Skin and Gums: A peculiar side effect seen in about 1% of female trial participants was hyperpigmentation darkening of the gums or skin (particularly on the face and breasts)

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In the meantime, a link between thyroid volume and Pb and Mn concentrations has been proposed, presuming that these metals may interfere with the thyroid gland either directly or indirectly by influencing iodine intake or thyroid hormone and TSH levels ( Volcanic activity is also related to an increase in environmental Radon concentrations, although a specific association of thyroid cancer with Radon levels has never been put forward ( Thus, studies to date regarding the role of environmental pollution with respect to thyroid function are still scarce, especially in childhood