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TB-500 human tolerability studies report mild adverse events at doses up to 1,260 mg [5] [11]

Prolonged use beyond 6 months should be discussed with a healthcare provider, as overuse may increase the risk of skin irritation or ochronosis (skin darkening)

Future studies will focus on the functional validation of these novel loci, including the integration of ocular-specific eQTL and gene expression data to elucidate the precise mechanisms, contribute to glaucoma pathogenesis

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