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Disease management includes the use of choline-restricted diets in affected individuals (114)

In addition, there was no significant linear relationship between dose (g/day) (coefficients = 0.02, p = 0.600) and duration of intervention (weeks) (coefficients = 0.54, p = 0.578) and changes in insulin (Figures 6B, 7B)

Ercal N, Gurer-Orhan H, Aykin-Burns N (2001) Toxic metals and oxidative stress part I: mechanisms involved in metal-induced oxidative damage

4D, diagram)

Both the SARC021 (in sarcoma patients) and MAESTRO (in pancreatic cancer patients), phase III trials showed that adding evofosfamide to standard chemotherapy (doxorubicin in soft-tissue sarcoma and gemcitabine in pancreatic cancer) failed to improve overall survival compared to chemotherapy alone (283, 284)