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may generate ROS not only in intracellular space but under certain conditions also in circulation, especially when their relevant substrates are present

McFarthing K, Buff S, Rafaloff G, Fiske B, Mursaleen L, Fuest R, Wyse RK, Stott SRW

doi: 10.1016/j.yebeh.2021.107841 90 TangP.LuQ.WuY.WangL.TangW.JiangY.et al

This is especially beneficial in cases where high drug concentrations are required to achieve the desired therapeutic effect

b - d , 3-month-old Mx1-Cre and Mx1-T3 mice were treated with -glucan or PBS and Lineage-negative cells were harvested 7 days later, differentiated into myeloid cells, treated with -glucan or PBS, further differentiated before LPS induction for 24 hr for cytokine production