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Pathophysiology of BPH To understand the risks, we need to look at what is happening inside

Trial SURPASS-2 (NEJM 2021) Population 1,879 adults with T2D vs semaglutide 1 mg

TRT has been used clinically since the 1950s when injectable testosterone esters were first developed

In order to improve outcomes, biphasic scaffolds can be created with a softer upper layer containing chondrogenic factors (e.g., TGF-, chondroitin sulfate) and a stiffer lower layer, often loaded with calcium phosphate, hydroxyapatite, or bone morphogenetic protein (BMP), to provide structural support of the above cartilage layer and to promote osteogenic tissue formation and boney integration