E., Schwartz, M., Lorke, D., and Schaude, G
Each of your cells contains glutathione, a substance created from three amino acids: cysteine, glutamate, and glycine
Valproic acid is contraindicated in patients known to have mitochondrial disorders caused by mutations in mitochondrial DNA polymerase (POLG
To address the limitations of current drug testing strategies mainly involving 2D cell cultures and animal testing, a three-dimensional microphysiological model of the human liver containing expandable human liver sinusoidal endothelial cells, monocyte-derived macrophages and differentiated HepaRG cells was utilized to investigate the toxicity of trovafloxacin and compared it to the structurally-related non-toxic drug levofloxacin
As expected, we observed that the loss-of-function mutant form of hHPN RS exhibited higher protein levels compared to the wild-type hHPN WT , both in serum and liver lysate